The integration of computer-aided design and manufacturing (CAD-CAM) technology has transformed dentistry, particularly in complete denture fabrication and maxillofacial prosthetics. CAD-CAM dentures offer enhanced fit, comfort, aesthetics, reduced fabrication time, and patient satisfaction compared to traditional methods. The fabrication process involves intraoral scanning, digital design, material selection, and milling or 3D printing. Future directions include biomimetic materials, AI integration, and open-source systems.3D printing has revolutionized maxillofacial prosthetics by providing personalized, precise solutions. It allows for customized prostheses tailored to the patient's unique anatomy, with advantages such as customization, precision, and efficiency. Digital scanning captures the patient's facial structure, facilitating the design of prostheses, which are then fabricated layer by layer using biocompatible materials. These advancements promise further improvements in CAD-CAM dentures and 3D printed maxillofacial prosthetics, ultimately benefiting patients globally.