Multiple sclerosis (MS) refers to a neurodegenerative disease. It has been characterized as a chronic immune-mediated disease, with strong neurodegenerative mechanisms in the progressive phase of the disease. Progressive multiple sclerosis is an advanced form of MS, categorized through the slow accumulation of disability over time without relapses. It is often manifested as a neurological development of one or more symptoms. Secondary progressive MS (SPMS) develops after an early relapsing course of the disease, whereas primary progressive MS (PPMS) develops gradually over time. Inflammation can also occur in PMS as aggregates of inflammatory cells in the meninges that includes a follicle-like presence. The diagnosis of PMS might be challenging, as it may remain unnoticed by physicians or patients for a long period. There are presently no recognized therapies for progressive forms of MS. This book aims to understand the clinical perspectives of multiple sclerosis. Some of the diverse topics covered herein address the causes, diagnoses and management of multiple sclerosis. The readers would gain knowledge that would broaden their perspective in this area.