This book consists of papers on the recent progresses in the state of the art in natural computation, fuzzy systems and knowledge discovery. The book is useful for researchers, including professors, graduate students, as well as R & D staff in the industry, with a general interest in natural computation, fuzzy systems and knowledge discovery. The work printed in this book was presented at the 2020 16th International Conference on Natural Computation, Fuzzy Systems and Knowledge Discovery (ICNC-FSKD 2020), held in Xi'an, China, from 19 to 21 December 2020. All papers were rigorously peer-reviewed by experts in the areas.