Russell Duvernoy develops ‘resonances’ between the metaphysics of Whitehead and Deleuze with regard to effects on attention and affect. The implications of these lead to an altered existential orientation, described by Duvernoy as ecological attunement. This original concept suggests that attention is ontologically creative, not just passively receptive, and feeling and affect are ontologically prior to the consolidation of lived subjectivity. The combined effects of these speculative claims cut deeply against the grain of prevailing habits with regard to subjectivity. Though these results are resolutely speculative, they unfold amidst intensifying ecological crisis and accompanying social, political and existential turbulence. What does it mean to pursue speculative thinking in this context? How do metaphysical concepts inform our lives and how might different concepts lead to different ways of life? Drawing on recent work by Massumi, Stengers, Debaise and Williams, this study explores their work in relation to other speculative trends in recent philosophy, including new materialisms, posthumanisms, speculative realism and object-oriented-ontology.