This book presents the role of AI-Driven Digital Twin in the Industry 4.0 ecosystem by focusing on Smart Manufacturing, sustainable development, and many other applications. It also discusses different case studies and presents an in-depth understanding of the benefits and limitations of using AI and Digital Twin for industrial developments. AI-Driven Digital Twin and Industry 4.0: A Conceptual Framework with Applications introduces the role of Digital Twin in Smart Manufacturing and focuses on the Digital Twin framework throughout. It provides a summary of the various AI applications in the Industry 4.0 environment and emphasizes the role of advanced computational and communication technologies. The book offers demonstrative examples of AI-Driven Digital Twin in various application domains and includes AI techniques used to analyze the environmental impact of industrial operations along with examples. The book reviews the major challenges in the deployment of AI-Driven Digital Twin in the Industry 4.0 ecosystem and presents an understanding of how AI is used in the designing of Digital Twin for various applications. The book also enables familiarity with various industrial applications of computational and communication technologies and summarizes the ongoing research and innovations in the areas of AI, Digital Twin, and Smart Manufacturing while also tracking the various research challenges along with future advances. This reference book is a must-read and is very beneficial to students, researchers, academicians, industry experts, and professionals working in related fields.