This book presents a groundbreaking exploration of humanity's quest for altered states, from ancient psychoactive rituals to immersive AI and virtual reality, and examines their continued impact on cognition, culture, governance, and identity. Drawing on decades of global fieldwork and interdisciplinary research, Dr Sheldon Lee Gosline traces compelling connections between the regulation of controlled substances and the addictive dynamics of emerging technologies. Readers are challenged to move beyond binaries of legality and pathology and discover how symbols, rituals, and imagination have long mediated our understanding of self and reality. Bridging anthropology, neuroscience, philosophy, and the history of medicine, chapters introduce innovative concepts such as symbolic entropy and recursive regulation to interpret present crises and anticipate future transformations. A must-read for scholars, policymakers, and curious readers alike, the volume offers a powerful lens through which to understand the evolving future of consciousness in the digital age.