This book deals with the importance of ambidexterity in innovation activities and global strategies. Ambidextrous global strategy (AGS) is crucial for global firms in the turbulent twenty-first century. Here, AGS is defined as simultaneous achievements of global integration and local adaptation, or responsiveness, through utilization of a firm's core facilities and organizational capabilities. To illustrate the specific implementation mechanism, a framework of AGS with global market strategy and organizational capability is shown for the purpose of analysis. There is also a focus on effective ambidextrous business strategies for the digital transformation era. Distinctive features of the book include, first, a framework of ambidextrous innovation and AGS. Second, there are analyses of examples of many industries to implement ambidexterity strategies, including Korean shipbuilding firms, Korean and Japanese steel firms, LCD panel flat-glass manufacturers, Japan's trucking industry, agricultural corporations, and other Japanese manufacturing firms. Finally, the book focuses on effective ambidextrous business strategies for the digital transformation era with the integration of open and closed innovation. The book presents specific business strategies for survival in the digital transformation era and then suggests an architectural analysis using artificial intelligence (AI) for the realization of AGS.  The target readership is made up of academics, students, and practitioners in the areas of global management, organizational theory, and strategic management. Especially for those readers, the book clarifies the critical practices and business strategies of innovative global firms in the era of digital transformation.