This book collects Thomas Nagel's recent philosophical reflections on topics of fundamental interest: ethics, moral psychology, science and religion, death, the holocaust, and the metaphysics of mind. Among the figures discussed are Peter Singer, Alvin Plantinga, Christine Korsgaard, Tony Judt, Elizabeth Anscombe, Philippa Foot, Iris Murdoch, T. M. Scanlon, Ronald Dworkin, Samuel Scheffler, Daniel Kahneman, Jonathan Haidt, Joshua Greene, and Daniel Dennett. Nagel consistently defends a realist interpretation of moral truth and resists reductive attempts to subsume ethics to psychology and evolutionary theory. He also defends a pluralistic conception of the content of morality as opposed to utilitarianism, one that includes deontological elements such as rights and special responsibilities. A realist outlook also informs his discussion of metaphysical and epistemological questions. The book closes with tributes to a number of people Nagel has known over the course of his career. The essays are all addressed to a general audience, and should appeal not only to philosophers but to anyone interested in current attempts to understand human life, human values, and how we fit into the world.