HPLC, LCMS/MS has become the preferred analytical methods for the Estimation of Pharmaceutical Drugs and related compounds due to its versatility, specificity and selectivity. And as Such the objectives of the present work are detailed as under.* To develop and validate Stability indicating analytical methods for separation, identification and Simultaneous estimation of some Pharmaceutical drugs using RP-HPLC, LCMS/MS, analytical methods.* To develop new analytical methods for some of the important drugs in pure and Pharmaceuticals dosage forms.* To conduct pharmacokinetic studies.The results collected from the above studies are useful for the proper review and assessment of the effectiveness and safety data obtained for the estimation of Pharmaceutical drugs.