Serious injury refers to physical trauma caused to a body by an external force that requires immediate medical attention or hospitalization. Falls, burns, acts of violence, road accidents, natural disasters, faulty products, and extreme sports may result in severe injuries. Serious injuries may, but not necessarily lead to permanent disability, impairment or disfigurement. Severe injuries not only involve the physical impact on the body of a patient, but it also affects emotional and mental health. These mental health issues can further have a negative impact on the rate of recovery. The mental health issues which can be caused due to a severe injury include post-traumatic stress disorder (PTSD), anxiety and depression. Post-traumatic stress disorder (PTSD) is a mental health condition that is triggered by a shocking event. This condition develops when the symptoms of trauma persist for weeks and months after the stressful event. Cognitive behavioral therapy (CBT) is a treatment therapy, which is used for a variety of mental health conditions such as anxiety disorders, depression, and PTSD. It helps people change their thought patterns in order to influence their behaviors and emotions. This book presents researches on various new diagnostic and therapeutic approaches for the care of severely injured patients. From theories to research to practical applications, clinical studies related to all contemporary topics of relevance to this area of medicine have been included herein.