This book constitutes the refereed proceedings of the 10th International Conference on Big Data, BigData 2021, held online as part of SCF 2021, during December 10-14, 2021. The 6 full and 2 short papers presented were carefully reviewed and selected from 53 submissions. The topics covered are Big Data Architecture, Big Data Modeling, Big Data As A Service, Big Data for Vertical Industries (Government, Healthcare, etc.), Big Data Analytics, Big Data Toolkits, Big Data Open Platforms, Economic Analysis, Big Data for Enterprise Transformation, Big Data in Business Performance Management, Big Data for Business Model Innovations and Analytics, Big Data in Enterprise Management Models and Practices, Big Data in Government Management Models and Practices, and Big Data in Smart Planet Solutions.