Breast cancer remains one of the most common cancers worldwide, with surgery still serving as the primary treatment modality. Up to 30% of breast cancers are impalpable at diagnosis, necessitating lesion localisation. Currently, wire-guided localisation remains the gold standard for managing non-palpable lesions. However, inherent limitations of this technique, combined with recent technological advances, have driven a progressive shift toward non-wire localisation methods. Similarly, the management of axillary tumours has evolved, moving from radical axillary surgery toward more conservative approaches, such as targeted axillary dissection. This book, the first dedicated solely to these topics, provides an up-to-date guide on current trends, advanced knowledge, and practical skills. To support practitioners-including surgeons, radiologists, radiographers, and multidisciplinary teams-in updating their skills for daily clinical practice, this work provides a comprehensive overview of current trends, emerging knowledge, and practical tips.