In this issue ofClinics in Laboratory Medicine, guest editor Dr. Jay Hudgins brings his considerable expertise to the topic ofEmerging Considerations in Transfusion Medicine . Top experts explain the new schema by which donors are screened for patients with an overview of the supportive data, challenges of the shrinking donor pool, and what is being done to address this looming shortfall. This issue also provides an overview of all current apheresis procedures, discusses gene therapy products for sickle cell and thalassemia, and offers a look toward the future, including the RMAT program, application of AI in blood donation surveillance, distribution, immunohematology assessment, and in-hospital utilization.