How do companies achieve the transformation into an agile, innovative, digital business and work environment? This question concerns not only IT managers but also strategic players, the enterprise architects. They must bridge the gap between strategic planning and dealing with increasing speed and growing uncertainty. Holistic enterprise development in the digital future means developing digital ecosystems and complex IT landscapes. This book presents methods and concepts from the agile world, semiotics, and neuropsychology that can help enterprise architects in their practical everyday work. Starting from a positive view of humanity, it is possible to harness the potential of individuals and teams for digital transformation with fundamental knowledge. The book is primarily aimed at IT managers, enterprise architects, and managers involved in large-scale software development processes. Many practical examples illustrate the theoretically presented connections and provide broader access to enterprise architecture management.