In the present study, Transdermal drug delivery of Ibuprofen was developed to overcome the first pass metabolism and to reduce frequency of dosing compared to oral route. Matrix type of Transdermal patches were developed by using polymers Eudragit-L100, HPMC K4M and HPMC K15M. Transdermal patches were prepared by employing solvent casting method. Propylene glycol and Tween80 were selected as Permeation enhancer and Plasticizer. Formulations were prepared with the varying concentrations polymers ranging from F1-F12, and all the formulations were evaluated for various physical parameters, In-vitro drug release studies by using dialysis membrane. Among all the formulations F6 formulation was found to be best and shown 96.5% drug release in 12 hours. For F6 formulation release kinetics were applied and it was observed that the formulation was following peppas mechanism of drug release. Drug excipient compatibility studies were carried out by using FTIR, and it was observed that they were no interactions.