This book constitutes revised selected papers from the 20th Workshop on e-Business, WeB 2021, which took place virtually on December 11, 2021. The purpose of WeB is to provide a forum for researchers and practitioners to discuss findings, novel ideas, and lessons learned to address major challenges and map out the future directions for e-Business. The WeB 2021 theme was "From Grand Challenges to Great Solutions: Digital Transformation in the Age of COVID-19." The 8 papers included in this volume were carefully reviewed and selected from a total of 24 submissions. The contributions are organized in topical sections as follows: digital innovation and transformation, and e-commerce and social media.