This book constitutes the refereed proceedings of the 6th Latin American High Performance Computing Conference, CARLA 2019, held in Turrialba, Costa Rica, in September 2019.  The 32 revised full papers presented were carefully reviewed and selected out of 62 submissions. The papers included in this book are organized according to the conference tracks - regular track on high performance computing: applications; algorithms and models; architectures and infrastructures; and special track on bioinspired processing (BIP): neural and evolutionary approaches; image and signal processing; biodiversity informatics and computational biology.