This book is a new exploration of the paradigm of innovation with Chinese characteristics in the context of a new era. Based on the evolution of innovation paradigm theories at domestic and international level, the book initiates a dialogue between Eastern and Western innovation theories. The book proposes "holistic innovation" which is defined as an open, collaborative, and total innovation under the guidance of strategy, in order to make effective allocation of resources. This book further discusses and summarizes the application of holistic innovation in the upgrading of global value chains, China's high value-added manufacturing, the urban Internet, rural development, and other related corporate and industrial cases, regional development, and national strategies.