This book constitutes the  refereed proceedings of the 17th International Conference on Information Security Practice and Experience, ISPEC 2022, held in Taipei, Taiwan, in November 2022. The 33 full papers together with 2 invited papers included in this volume were carefully reviewed and selected from 87 submissions. The main goal of the conference is to promote research on new information security technologies, including their applications and their integration with IT systems in various vertical sectors.