This book presents the proceedings of the KES International Conferences on Innovation in Medicine and Healthcare (KES-InMed-25), held in Solin, Croatia, on June 25&27, 2025. Covering several key areas, including digital IT architecture in healthcare; advanced ICT for medicine and healthcare; biomedical engineering, trends, research, and technologies; and healthcare support systems, this book is a valuable resource for researchers, managers, industrialists, and anyone wishing to gain an overview of the latest research in these fields.