In this issue of Hematology/Oncology Clinics , guest editor Dr. P. Leif Bergsagel brings his considerable expertise to the topic of New Developments in Myeloma . With the advent of next generation sequencing and immune profiling technologies, marked advances have been made recently in the understanding of the molecular and immune pathogenesis of multiple myeloma. Yet even with these advances, there is a continual search for new therapeutic approaches. In this issue, top experts discuss a full range of clinically relevant topics in this complex and fast-changing field.