Finding that they are uniquely equipped to work together, as Tim is the only human who can talk with Pikachu, they join forces on a thrilling adventure to unravel the tangled mystery. Chasing clues together through the neon-lit streets of Ryme City--a sprawling, modern metropolis where humans and Pokémon live side by side in a hyper-realistic live-action world-- they encounter a diverse cast of Pokémon characters and uncover a shocking plot that could destroy this peaceful co-existence and threaten the whole Pokémon universe.