Contamination of food and feed products with mycotoxins represent a major threat to human and animal health, and are a significant food safety concern to the worldwide agriculture and food value chain. Due to its high prevalence, costs related to avoiding the occurrence of mycotoxins in food and feed are continuing to rise, causing the international economy to lose billions of dollars every year. The fact is that currently mycotoxin contamination cannot be avoided using the current agricultural practices, therefore, innovative strategies for mitigating mycotoxins are essential and urgently needed. After several decades of research, our understanding of mycotoxin mitigation started to reach a pinnacle and major advances in the control of mycotoxins have been achieved. One of the advances is the development of mycotoxin detoxifications, particularly by biological and enzymatic means. This book covers the most recent advances related to the detoxifications of mycotoxins in food and feed and presents the most promising techniques that may lead to optimized empirical and feasible solutions for controlling mycotoxins in the agriculture and food value chain. The book also provides comprehensive strategies with state-of-the-art tools for future research and development in the field of mycotoxin detoxifications.