This volume presents an up-to-date overview of the current state-of-the-art protocols, and aims to put proteogenomics into a broader perspective. The chapters in this book detail methods and techniques ranging from mass spectrometry to proteomics and proteogenomics and their biomedical implications and applications. Written in the highly successful Methods in Molecular Biology series format, the chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. A highlight for everyone new to the field are the chapters, which put proteogenomics to use to answer biomedical questions. Authoritative and accessible, Proteogenomics: Methods and Protocols aims to ensure successful results in the further study of this vital field.