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This book presents a distinctive and integrative perspective on the role of protein misfolding and proteostasis in two major disease areas, cancer and neurodegeneration. The book explores how disruptions in protein homeostasis contribute to pathological outcomes, highlighting both the adaptive exploitation of proteostasis networks in cancer and their collapse in neurodegenerative disorders such as Alzheimer's, Parkinson's, ALS, and Huntington's disease. The volume is organized into four sections. It begins with foundational concepts in proteostasis, including protein folding, aggregation, and cellular quality control systems. The second section examines how cancer cells manipulate chaperones, the unfolded protein response, and degradation pathways to survive stress. The third section focuses on neurodegeneration and explains how proteostasis failure leads to toxic protein accumulation and neuronal death. The final section brings together insights from both fields and identifies shared molecular mechanisms and opportunities for therapeutic strategies that apply across diseases. The book also discusses emerging technologies such as AI-driven structural biology, molecular dynamics simulations, nanomedicine, and PROTACs. It addresses challenges in translating research into clinical applications and outlines a path toward developing future therapies that target proteostasis. This volume is intended for researchers, clinicians, and students in molecular medicine, neuroscience, cancer biology, and drug discovery.
This book presents a distinctive and integrative perspective on the role of protein misfolding and proteostasis in two major disease areas, cancer and neurodegeneration. The book explores how disruptions in protein homeostasis contribute to pathological outcomes, highlighting both the adaptive exploitation of proteostasis networks in cancer and their collapse in neurodegenerative disorders such as Alzheimer's, Parkinson's, ALS, and Huntington's disease. The volume is organized into four sections. It begins with foundational concepts in proteostasis, including protein folding, aggregation, and cellular quality control systems. The second section examines how cancer cells manipulate chaperones, the unfolded protein response, and degradation pathways to survive stress. The third section focuses on neurodegeneration and explains how proteostasis failure leads to toxic protein accumulation and neuronal death. The final section brings together insights from both fields and identifies shared molecular mechanisms and opportunities for therapeutic strategies that apply across diseases. The book also discusses emerging technologies such as AI-driven structural biology, molecular dynamics simulations, nanomedicine, and PROTACs. It addresses challenges in translating research into clinical applications and outlines a path toward developing future therapies that target proteostasis. This volume is intended for researchers, clinicians, and students in molecular medicine, neuroscience, cancer biology, and drug discovery.
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