Jan Nesemann studies relatively bounded perturbations of self-adjoint operators in Krein spaces with real spectrum. The main results provide conditions which guarantee the spectrum of the perturbed operator to remain real. Similar results are established for relatively form-bounded perturbations and for pseudo-Friedrichs extensions. The author pays particular attention to the case when the unperturbed self-adjoint operator has infinitely many spectral gaps, either between eigenvalues or, more generally, between separated parts of the spectrum.