This book constitutes revised selected papers of the 10th International Conference on Analysis of Images, Social Networks and Texts, AIST 2021, held in Tbilisi, Georgia, in December 2021. Due to the COVID-19 pandemic the conference was held in hybrid mode.  The 17 full papers were carefully reviewed and selected from 118 submissions, out of which 92 were sent to peer review. The papers are organized in topical sections on natural language processing; computer vision; data analysis and machine learning; social network analysis; theoretical machine learning and optimisation.