The Inflammatory Ecosystem and Inflammazones offers a groundbreaking framework for understanding inflammation across multiple spatial and molecular levels. It introduces the concept of distinct inflammazones-local, regional, distal, and systemic-and explores how their interactions influence disease development, progression, and resolution. This holistic approach integrates cellular, molecular, microbiome, and systemic responses, addressing a critical gap in current knowledge and advancing diagnostics and therapies for diseases like autoimmunity and cancer. The book is organized into six sections, starting with foundational principles and progressing through mechanisms of local, regional, and systemic inflammazones. It covers key components such as cytokines, chemokines, immune cells, and the roles of non-immune cells like fibroblasts and epithelial cells. The final sections focus on systems-level insights, including inflammaging, metabolism, and multi-omics technologies, culminating in strategies for personalized medicine and clinical translation. Each chapter combines cutting-edge research with clinical relevance, making complex concepts accessible and actionable. The Inflammatory Ecosystem and Inflammazones is essential for researchers and clinicians seeking to understand the complex landscape of inflammation. It highlights disease heterogeneity, emerging therapeutic targets, and the importance of systems biology, providing the foundational knowledge to shape future inflammation research and treatment strategies. Presents the innovative concept of inflammazones, redefining the spatial organization of inflammation Integrates molecular, cellular, and systemic perspectives for a comprehensive understanding of inflammatory diseases Highlights emerging therapeutic targets within distinct inflammazones for personalized treatment strategies Connects basic research with clinical applications, enhancing diagnostic and intervention approaches Provides a systems-level framework to explore inflammation&s role in chronic and age-related diseases