The Oxford Handbook of Philosophy of Political Science contains twenty-seven freshly written chapters to give the reader a panoramic introduction to philosophical issues in the practice of political science. Simultaneously, it advances the field of Philosophy of Political Science by creating a fruitful meeting place where both philosophers and practicing political scientists contribute and discuss. These philosophical discussions are close to and informed by actual developments in political science, making philosophy of science continuous with the sciences, another aspiration that motivates this volume. The chapters fall under four headings: (1) evaluating theoretical frameworks in political science; (2) methodological challenges and reconciliations; (3) the purposes and uses of political science; and, (4) the interactions between political science and society. Specific topics discussed include the biology of political attitudes, intra-agent mechanisms, rational choice explanations, theories of collective action, explaining institutional change, conceptualizing and measuring democracy, process tracing, qualitative comparative analysis, interpretivism and positivism, mixed methods, within-cause causal inference, evidential pluralism, lab and field experiments, external validity, contextualization, prediction, expertise, clientelism, feminism, values, and progress in political science.