This book constitutes the proceedings papers of the 14th IFIP Working Conference on the Practice of Enterprise Modeling, held in Riga, Latvia, during November 24-26, 2021. PoEM offers a forum for sharing experiences and knowledge between the academic community and practitioners from industry and the public sector. This year the theme of the conference is the use of enterprise modeling and enterprise architecture towards ensuring sustainability and resilience of enterprises and societies. The 14 full and 6 short papers presented in this volume were carefully reviewed and selected from a total of 47 submissions. They were organized in topical sections named: enterprise modeling and enterprise architecture; enterprise modeling methods and method engineering; business process modeling and management; requirements engineering for privacy, security and governance; and case studies and experiences.