Marie du Trieux, a tavern keeper with a salty tongue and a heart of gold, struggles as she navigates love and loss, Native wars, and possible banishment by authorities in the unruly trading port of New Amsterdam, an outpost of the Dutch West India Company. In New England, John Tinker, merchant and assistant to a renowned alchemist and eventual leader of Connecticut Colony, must come to terms with a family tragedy of dark proportions, all the while supporting his mentor's secret quest to find the Northwest Passage, a desired trading route purported to mystically unite the East with the West. As the lives of Marie and John become intertwined through friendship and trade, a search for justice of a Dutch woman accused of witchcraft in Hartford puts them on a collision course affecting not only their own destinies but also the fate of colonial America.