This online Clinics series provides evidence-based answers to clinical questions that practicing hospitalists face daily. This issue of Hospital Medicine Clinics is Guest Editored by Dr. Mark Thoelke. Dr. Thoelke has assembled a group of expert authors to review the following topics: Diastolic Dysfunction; Acute Bronchospasm and Asthma; Fungemia in the Hospitalized Patient; Renal-Obsructive Uropathy; Diagnosis and Management of Cholecystitis, Choledocholithiasis, and Other Bililary Disorders; Reservible Posterior Leukoencephalopathy Syndrome; Paraneoplastic Disorders; All You Need to Know About Prescribing Methadone; Caring for the Actively Dying; and When the patient wants to leave against medical advice: Considerations for the hospitalist and the patient.